24. The COVID Vaccine with Paul Offit

World-renowned vaccine expert Paul Offit discusses where we stand with the development of a COVID-19 vaccine, challenges ahead, and how clinicians can best focus our efforts in vaccine education and advocacy. Guest Bio: Paul Offit is a pediatrician specializing in infectious diseases and an expert on vaccines, immunology, and virology. He is the co-inventor of a rotavirus vaccine that has been credited with saving hundreds of lives every day. Offit is the Maurice R. Hilleman professor of vaccinology, professor of pediatrics at the Perelman School of Medicine at the University of Pennsylvania and director of The Vaccine Education Center at Children’s Hospital of Philadelphia (CHOP). Offit is currently a member of National Institutes of Health (NIH) working group on vaccines, a subgroup of the “Accelerating COVID-19 Therapeutic Interventions and Vaccines” (ACTIV) comprised of experts to combat COVID-19. He is also a member of the FDA’s Vaccines and Related Biological Products Advisory Committee (VRBPAC). Previously, he was a member of the Centers for Disease Control and Prevention’s (CDC) Advisory Committee on Immunization Practices. Offit is a board member of Vaccinate Your Family and Autism Science Foundation. “Overkill” is his 11th book. This podcast is produced in partnership with Hippo Education

How the COVID vaccine is being made and where it targets the virus
Different variations of the vaccine
The normal path to vaccine development and how it’s different with this one
Why Paul Offit would opt for wearing a mask vs getting a vaccine if he had to choose between the two
How to balance the urgency for the need for a vaccine with safety concerns
What happens in Phase 1, 2, and 3 trials
Likelihood the vaccine will be rushed to market

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References:

O’Callaghan KP, Blatz AM, Offit PA. Developing a SARS-CoV-2 Vaccine at Warp Speed. JAMA. 2020;324(5):437–438. doi:10.1001/jama.2020.12190
Lurie N, Sharfstein JM, Goodman JL. The Development of COVID-19 Vaccines: Safeguards Needed. JAMA. 2020;324(5):439–440. doi:10.1001/jama.2020.12461
Chugh T. Timelines of COVID-19 vaccines. Curr Med Res Pract. 2020;10(4):137-138. doi:10.1016/j.cmrp.2020.07.009
Amanat F, Krammer F. SARS-CoV-2 Vaccines: Status Report. Immunity. 2020;52(4):583-589. doi:10.1016/j.immuni.2020.03.007